Identifying the protein kinases involved in cellular dysfunction and cancer development could yield many new drug targets, but for the vast majority of these kinases, scientists don't have a clear ...

There is growing enthusiasm in the pharmaceutical industry for whole-system functional assays that reveal the action of potential drugs on integrated systems such as intact cells in order to find ...

A team of researchers from the Keck School of Medicine of USC has unlocked the details of a cellular pathway that triggers cellular inflammation and aging and is linked to Alzheimer's disease, ...

A distinct signaling pathway called TNF-α drives the transformation of epithelial cells into aggressive tumor cells. During cancer progression, cells activate their own TNF-α program and become ...

Scientists identify measurable cellular changes that flag higher cancer risk more than a decade before tumors appear. In A ...

Using cutting-edge bioinformatics techniques for gene identification and sequencing, researchers are comprehensively mapping signaling pathway distributions in both normal and acne-affected skin. Acne ...

One of the most important classes of human enzymes are protein kinases - signaling molecules that regulate nearly all cellular activities, including growth, cell division, and metabolism. Dysfunction ...

How can we improve drug specificity? Larger, more complex drugs may be the way to target ‘undruggable’ cell targets, but how are these drugs taken up by cells? Researchers at the University of ...

Autophagy—meaning "self-eating" in Greek—is a fundamental cellular mechanism that preserves cell health by recycling and degrading worn-out or dysfunctional components. Serving as an essential ...