Two types of parietal podocyte were previously described in the Bowman capsule: one characterized by coexpression of podocyte and parietal epithelial cell markers, the other characterized by ...

A new study demonstrates that knockdown of miR-193a in human parietal epithelial cells induces their differentiation into podocytes. Inhibition of miR-193a in a model of nephrotoxic nephritis resulted ...

Unlike other human stem cells, Induced pluripotent stem cells (iPS cells) can be produced directly from adult cells. Now, researchers have shown that human kidney podocytes produced from iPS cells via ...

IgA nephropathy is an autoimmune kidney disease, and complement, a component of the innate immune system, plays a role in the condition's pathogenesis. Investigators have developed and tested a novel ...

BUFFALO, NY-August 8, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 14, entitled, “Inhibiting ...

A newly-established protocol offers hope for kidney disease modeling, drug discovery, and potential cell therapies. Previous work from the Wyss Institute at Harvard University established a protocol ...

CCL5 is a signaling molecule, or chemokine, that helps immune cells move toward sites of inflammation. It was first identified in T cells, but later research showed that it is also produced by other ...

A fasting-mimicking diet may promote renoprotection by reducing proteinuria and improving endothelial function. Cycles of controlled fasting may promote regeneration of podocytes in patients with ...

Podocytes are a terminally differentiated cell type located in the glomerulus. Podocyte damage and the subsequent dysregulation of podocyte proteins have been implicated in various kidney disorders.

A research team from the Medical University of Vienna has investigated structural changes in kidneys of patients with hypertension and type 2 diabetes. The results show that high blood pressure can ...

Chronic kidney disease (CKD) affects more than 10% of the global population and is expected to become the fifth leading cause of death worldwide within the next two decades. Perhaps surprisingly, ...

CCL5 protects podocytes, the kidney’s essential filtration cells, but simultaneously drives harmful inflammation. Ultimately, these damaging effects surpass its protective role, leading to progressive ...